منابع مشابه
PPARs and Anticancer Therapies
1Department of Radiation Oncology, Brain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA 2 Institute for Radioprotection and Nuclear Safety, 92262 Fontenay aux Roses Cedex, France 3Vascular Biology Program, Children’s Hospital, Harvard Medical Center, Boston, MA 02115, USA 4Department of Pediatric Oncology, Dana-Fa...
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The metabolic/cell signaling basis of Warburg's effect ("aerobic glycolysis") and the general metabolic phenotype adopted by cancer cells are first reviewed. Several bypasses are adopted to provide a panoramic integrated view of tumoral metabolism, by attributing a central signaling role to hypoxia-induced factor (HIF-1) in the expression of aerobic glycolysis. The cancer metabolic phenotype al...
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Neuroepithelial tumors represent a heterogeneous class of human tumors including benignant and malignant tumors. The incidence of central nervous system neoplasms ranges from 3.8 to 5.1 cases per 100,000 in the population. Among malignant neuroepithelial tumors, with regard to PPAR ligands, the most extensively studied were tumors of astrocytic origin and neuroblastoma. PPARs are expressed in d...
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Circadian variation in drug metabolism and tissue sensitivity to drugs affects their activity and toxicity. A growing body of data suggests that therapy may be improved and toxicity reduced by administering antineoplastic agents at carefully selected times of the day. Here I briefly review molecular, cellular, and organismic time-keeping mechanisms as well as cytokinetic, pharmacokinetic, and p...
متن کامل11th International Congress on Targeted Anticancer Therapies
paris, france, 4–6 March 2013 The Targeted Anticancer Therapies (TAT) conference provides a forum for in-depth discussion of emerging targeted agents for the treatment of cancer. TAT conferences are characterized by focus on emerging innovative agents with a cancer-specific molecular target, gathering the world’s leading oncology Phase I investigators. They attract a mix of professionals with d...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2010
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2010/536415